Watanabe Lab


Hamaguchi, K., Takahashi-Aoki, H., and Watanabe, D. (2022). From Retrospective to Prospective: Integrated Value Representation in Frontal Cortex for Predictive Choice Behavior.
Proc. Natl. Acad. Sci. U S A in press.
Sato, D., Narita, M., Hamada, Y., Mori, T., Tanaka, K., Tamura, H., Yamanaka, A., Matsui, R., Watanabe, D., Suda, Y., Senba, E., Watanabe, M., Navratilova, E., Porreca, F., Kuzumaki, N., and Narita, M. (2022). Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons.
Mol Brain 15, 10.
Narihara, I., Kitajo, K., Namba, H., Sotoyama, H., Inaba, H., Watanabe, D., and Nawa, H. (2021). Rat Call-Evoked Electrocorticographic Responses and Intercortical Phase Synchrony Impaired in a Cytokine-Induced Animal Model for Schizophrenia.
Neurosci Res.
Ito, T., Ono, M., Matsui, R., Watanabe, D., and Ohmori, H. (2021). Avian adeno-associated virus as an anterograde transsynaptic vector.
J Neurosci Meth 359, 109221.
Sotoyama, H., Namba, H., Kobayashi, Y., Hasegawa, T., Watanabe, D., Nakatsukasa, E., Sakimura, K., Furuyashiki, T., and Nawa, H. (2021). Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.
Translational Psychiatry 11, 236.
Horie, T., Nakao, T., Miyasaka, Y., Nishino, T., Matsumura, S., Nakazeki, F., Ide, Y., Kimura, M., Tsuji, S., Rodriguez, R.R., Watanabe, T., Yamasaki, T., Xu, S., Otani, C., Miyagawa, S., Matsushita, K., Sowa, N., Omori, A., Tanaka, J., Nishimura, C., Nishiga, M., Kuwabara, Y., Baba, O., Watanabe, S., Nishi, H., Nakashima, Y., Picciotto, MR., Inoue, H., Watanabe, D., Nakamura, K., Sasaki, T., Kimura, T., and Ono, K. (2021). microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.
Nature Communications 12, 843.
Sugiyama, T., Yamamoto, H., Kon, T., Chaya, T., Omori, Y., Suzuki, Y., Abe, K., Watanabe, D., and Furukawa, T. (2020). The potential role of Arhgef33 RhoGEF in foveal development in the zebra finch retina.
Scientific Reports 10, 21450.
Nishioka, T., Hamaguchi, K., Yawata, S., Hikida, T., and Watanabe, D. (2020). Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in Mice.
Frontiers in Systems Neuroscience 14, 38.
Lee, S., Hayakawa, T., Nishimura, C., Yawata, S., Watanabe, D., and Ishikawa, M. (2019). Movement Analysis for Volitional Direction Change of Laboratory Mouse based on High-Speed Imaging.
Imaging and Applied Optics 2019 Cosi Math Pcaop IW1C.1.
Okunomiya, T., Hioki, H., Nishimura, C., Yawata, S., Imayoshi, I., Kageyama, R., Takahashi, R., and Watanabe, D. (2019). Generation of a MOR‐CreER knock‐in mouse line to study cells and neural circuits involved in mu opioid receptor signaling.
Genesis e23341.
Imamura, K., Izumi, Y., Watanabe, A., Tsukita, K., Woltjen, K., Yamamoto, T., Hotta, A., Kondo, T., Kitaoka, S., Ohta, A., et al. (2017). The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Science Translational Medicine 9, eaaf3962.
Tohyama, T., Kinoshita, M., Kobayashi, K., Isa, K., Watanabe, D., Kobayashi, K., Liu, M., and Isa, T. (2017) Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
Proc. Natl. Acad. Sci. U S A 114, 604–609.
Deguchi, Y., Harada, M., Shinohara, R., Lazarus, M., Chérasse, Y., Urade, Y., Yamada, D., Sekiguchi, M., Watanabe, D., Furuyashiki, T., and Narumiya, S. (2016) mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.
Cell Rep.17, 2405–2417.
Imamura, K., Sahara, N., Kanaan, N. M., Tsukita, K., Kondo, T., Kutoku, Y., Ohsawa, Y., Sunada, Y., Kawakami, K., Hotta, A., Yawata, S., Watanabe, D., Hasegawa, M., Trojanowski, J. Q., Lee, V. M.-Y., Suhara, T., Higuchi, M., and Inoue, H. (2016) Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.
Sci. Rep. 6, 34904.
Abe, K., Matsui, S., and Watanabe, D. (2015). Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor.
Proc Natl Acad Sci U S A 112, 7599-7604.
Hasegawa, T., Fujimoto, H., Tashiro, K., Nonomura, M., Tsuchiya, A., and Watanabe, D. (2015). A wireless neural recording system with a precision motorized microdrive for freely behaving animals.
Sci. Rep. 5, 7853.
Watakabe, A., Takaji, M., Kato, S., Kobayashi, K., Mizukami, H., Ozawa, K., Ohsawa, S., Matsui, R., Watanabe, D., and Yamamori, T. (2014). Simultaneous visualization of extrinsic and intrinsic axon collaterals in Golgi-like detail for mouse corticothalamic and corticocortical cells: a double viral infection method.
Front Neural Circuits 8.
Sooksawate, T., Isa, K., Matsui, R., Kato, S., Kinoshita, M., Kobayashi, K., Watanabe, D., Kobayashi, K., and Isa, T. (2013). Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice.
Front Neural Circuits 7.
Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O., Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S.-I., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., and Inoue, H. (2013). Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness.
Cell Stem Cell 12, 487–496.
Matsui, R., Tanabe, Y., and Watanabe, D. (2012). Avian Adeno-Associated Virus Vector Efficiently Transduces Neurons in the Embryonic and Post-Embryonic Chicken Brain.
PLoS ONE 7, e48730.
Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H. (2012). Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells.
Science Transl Med 4, 145ra104.
Kinoshita, M., Matsui, R., Kato, S., Hasegawa, T., Kasahara, H., Isa, K., Watakabe, A., Yamamori, T., Nishimura, Y., Alstermark, B., Watanabe, D., Kobayashi, K., and Isa, T. (2012). Genetic dissection of the circuit for hand dexterity in primates.
Nature 487, 235–238.
Fujimoto, H., Hasegawa, T., and Watanabe, D. (2011). Neural coding of syntactic structure in learned vocalizations in the songbird.
J Neurosci 31, 10023–10033.
Abe, K., and Watanabe, D. (2011). Songbirds possess the spontaneous ability to discriminate syntactic rules.
Nat Neurosci 14, 1067–1074.
Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y., Irie, S., Uneo, S., Koyasu, T., Matsui, R., Chérasse, Y., Urade, Y., Watanabe, D., Kondo, M., Yamashita, T., and Furukawa, T. (2011). miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression.
Nat Neurosci 14, 1125-1134.
Murata, K., Imai, M., Nakanishi, S., Watanabe, D., Pastan, I., Kobayashi, K., Nihira, T., Mochizuki, H., Yamada, S., Mori, K., and Yamaguchi, M. (2011). Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb.
J Neurosci 31, 10540–10557.
Kaneda, K., Kasahara, H., Matsui, R., Katoh, T., Mizukami, H., Ozawa, K., Watanabe, D., and Isa, T. (2011). Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin.
PLoS ONE, e18452.
Fujimoto, H., Hasegawa, T., Matsui, R., Abe, K., and Watanabe, D. (2009). The mechanisms of the motor programming for learned vocalization in songbird.
In Systems Biology: the Challenge of Complexity. Nakanishi S., Kageyama R., and Watanabe D. eds., Springer.
Wada, N., Kishimoto, Y., Watanabe, D., Kano, M., Hirano, T., Funabiki, K., and Nakanishi, S. (2007). Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission.
Proc Natl Acad Sci U S A 104, 16690-95.
Nakanishi S., Kaneko S., Hikida T., Watanabe D., and Pastan I. (2003). Role of synaptic integration of dopaminergic and cholinergic transmissions in basal ganglia function.
In Cognition and Emotion in the Brain, 487-92. Ono T., Matsumoto G., Llinas RR., Berthoz A., Norgen R., Nishijo H., and Tamura R. eds., Elsevier Science.
Watanabe, D., and Nakanishi, S. (2003). mGluR2 postsynaptically senses granule cell inputs at Golgi cell synapses.
Neuron 39, 821-29.
Yamamoto, M., Wada, N., Kitabatake, Y., Watanabe, D., Anzai, M., Yokoyama, M., Teranishi, Y., and Nakanishi, S. (2003). Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain.
J Neurosci 23, 6759-767.
Soda, T., Nakashima, R., Watanabe, D., Nakajima, K., Pastan, I., and Nakanishi, S. (2003). Segregation and coactivation of developing neocortical layer 1 neurons.
J Neurosci 23, 6272-79.
Kitabatake, Y., Hikida, T., Watanabe, D., Pastan, I., and Nakanishi, S. (2003). Impairment of reward-related learning by cholinergic cell ablation in the striatum.
Proc Natl Acad Sci U S A 100, 7965-970.
Hazama, M., Watanabe, D., Suzuki, M., Mizoguchi, A., Pastan, I., and Nakanishi, S. (2002). Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice.
Brain Res Mol Brain Res 100, 53-66.
Hirano, T., Watanabe, D., Kawaguchi, S.Y., Pastan, I., and Nakanishi, S. (2002). Roles of inhibitory interneurons in the cerebellar cortex.
Ann N Y Acad Sci 978, 405-412.
Yoshida, K., Watanabe, D., Ishikane, H., Tachibana, M., Pastan, I., and Nakanishi, S. (2001). A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.
Neuron 30, 771-780.
Hikida, T., Kaneko, S., Isobe, T., Kitabatake, Y., Watanabe, D., Pastan, I., and Nakanishi, S. (2001). Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens.
Proc Natl Acad Sci U S A 98, 13351-54.
Kaneko, S., Hikida, T., Watanabe, D., Ichinose, H., Nagatsu, T., Kreitman, R.J., Pastan, I., and Nakanishi, S. (2000). Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
Science 289, 633-37.
Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., et al. (1998). Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
Cell 95, 17-27.
Nakanishi, S., Nakajima, Y., Masu, M., Ueda, Y., Nakahara, K., Watanabe, D., Yamaguchi, S., Kawabata, S., and Okada, M. (1998). Glutamate receptors: brain function and signal transduction.
Brain Res Brain Res Rev 26, 230-35.